Understanding the Potential Side Effects of GLP-1 Medications
- Ms. Shamika
- Dec 8, 2025
- 3 min read
GLP-1 medications have gained attention for their role in managing type 2 diabetes and supporting weight loss. These drugs mimic the glucagon-like peptide-1 hormone, which helps regulate blood sugar and appetite. While many people benefit from GLP-1 treatments, it is important to understand the potential side effects that can come with their use. This article explores common and less common side effects, how to manage them, and when to seek medical advice.
We also encourage you to consider combining GLP-1s with nutrition and exercise. Click here to learn more.
Common Side Effects of GLP-1 Medications
Many patients encounter mild side effects when beginning GLP-1 medications. These side effects often improve as the body adapts to the drug, especially with the addition of GOOD NUTRITION and EXERCISE.
Nausea and Vomiting
Nausea is the side effect reported most often. It typically appears within the initial weeks of treatment and generally diminishes over time. Vomiting can occur alongside nausea, though it is less frequent.
Diarrhea or Constipation
Alterations in bowel habits are frequent. Some individuals encounter diarrhea, whereas others might experience constipation. These symptoms typically improve with increased physical activity and exercise.
Loss of Appetite
GLP-1 medications suppress appetite, which can aid in weight loss but might lead to reduced food consumption. This is an anticipated outcome, yet it should be observed to prevent malnutrition, along with receiving nutritional guidance and preparing meals appropriately.
Indigestion and Stomach Pain
Some users experience stomach discomfort or indigestion. While this can be mild, it is advisable to consult a healthcare provider if it persists. It is best to avoid spicy and greasy foods, as they can heighten the chances of nausea and heartburn.
Less Common but Serious Side Effects
While rare, some side effects require immediate medical attention.
Pancreatitis
Inflammation of the pancreas is a serious condition linked to GLP-1 medications in some cases. Symptoms include severe abdominal pain, nausea, and vomiting. If these occur, stop the medication and seek emergency care.
Kidney Problems
Vomiting or diarrhea-induced dehydration can impact kidney function. Individuals with pre-existing kidney problems require careful monitoring. Personally, I've become very attuned to my body's need for water and have consistently needed to double my water intake.
Allergic Reactions
Although rare, temporary allergic reactions like rash, itching, or swelling can occur at the injection site. Severe reactions might include difficulty breathing and necessitate urgent medical attention.
Managing Side Effects Effectively
Adjusting to GLP-1 medications can be smoother with some practical steps.
Start with a Low Dose
Our doctor typically begins my clients on a low dose and gradually raises it. This method helps minimize nausea and other digestive symptoms.
Eat Smaller, Frequent Meals
Smaller portions spread throughout the day can ease nausea and prevent stomach discomfort.
Stay Hydrated
Drinking plenty of water helps manage side effects like constipation and supports kidney health.
Avoid Fatty or Spicy Foods
These can worsen digestive symptoms during the initial treatment phase.
Communicate with Your Healthcare Provider & Patient Support Team
We offer our clients a patient support team that they can text to report any ongoing or severe side effects right away. The doctor might then adjust the dosage or recommend alternative treatments.
Who Should Be Cautious with GLP-1 Medications
Certain groups need extra caution when using these drugs.
People with a history of pancreatitis
Those with severe kidney disease
Individuals with a personal or family history of medullary thyroid carcinoma
Pregnant or breastfeeding women (safety not well established)
Complete our intake forms with your comprehensive medical history so that our doctor and patient care team can review it before prescribing. Ensure you consult your primary healthcare provider before beginning GLP-1 therapy.
What to Expect When Using GLP-1 Medications
Most people tolerate GLP-1 drugs well after the initial adjustment period. Side effects usually lessen within a few weeks. The benefits, such as improved blood sugar control and weight loss, often outweigh the temporary discomfort.
If side effects continue for more than a month or become more severe, contact our patient care team. They might adjust your dosage or prescribe a different medication.
Final Thoughts on GLP-1 Medication Side Effects
Understanding the potential side effects of GLP-1 medications helps users prepare and respond appropriately. Mild digestive symptoms are common but tend to improve with time and proper management. Serious side effects are rare but require prompt medical attention.
If you or someone you know is considering or currently using GLP-1 medications, give us a call (803.599.6339), chat/email (Info@thewellnessco.site) or simply book an Advanced Body Composition Session Using the link below. We would love to work with you!
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